Calcium and phosphate metabolism management in chronic renal disease calcium and phosphate metabolism management in chronic renal disease edited by chen hsing hsu md professor of internal medicine the university of michigan and difficult problems in chronic kidney disease ckd this book is intended. Chronic kidney disease ckd causes imbalances in bone metabolism and increases the risk of a type of bone disease called renal osteodystrophy these imbalances also can cause calcium to deposit in the blood vessels and contribute to heart disease. In chronic kidney disease ckd the kidneys fail to excrete the phosphorus and the result is a positive phosphorus balance however the skeleton through the disorders of the bone that accompany ckd contributes to this hyperphosphatemic state as it can not handle the phosphorus excess. The nephrologists role in the management of calcium phosphorus metabolism in patients with chronic kidney disease background in patients with chronic kidney disease ckd timely referral to a nephrologist has been shown to improve outcomes but the specific care measures mediating these superior outcomes have not been sufficiently described. Disturbances of calcium phosphate ca p metabolism in chronic renal insufficiency cri play an important role not only in bone disease renal osteodystrophy but also in soft tissue calcification with an increased risk of vascular calcification arterial stiffness and worsening of atherosclerosis
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