Cell volume regulation following cell shrinkage involves accumulation of ions through activation of na k 2cl cotransport na h exchange in parallel to cl hco3 exchange or na channels the na taken up is extruded by the na k atpase in exchange for k . 2 factors determining cell volume under steady state conditions 3 physiological and pathological causes of non balanced cell volume changes 4 general mechanisms of cell volume regulation under non steady state conditions 41 membrane transporters mediating rvd 42 membrane transporters mediating rvi 43. Cell volume regulation in the brain 11 cell volume control in healthy brain and neuropathologies corinne s wilson and alexander a mongin 12 cytotoxic swelling of sick excitable cells impaired ion omeostasis and membrane tension homeostasis in muscle and neuron catherine e morris . Cell volume regulation is of special importance in liver since these cells receive dual perfusion from both the systemic and portal circulations and are exposed to unusually large changes in the concentrations of solutes such as amino acids bile acids and glucose between the fed and fasted states. Cell volume is a major factor in the regulation of cell cycle progression with cell proliferation generally being inhibited by cell shrinkage and stimulated by cell swelling respectively anbari and schultz 1993 dubois and rouzaire dubois 2004 rouzaire dubois et al 2005
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