Cholestasis is defined as a decrease in bile flow due to impaired secretion by hepatocytes or to obstruction of bile flow through intra or extrahepatic bile ducts therefore the clinical definition of cholestasis is any condition in which substances normally excreted into bile are retained. Intrahepatic cholestasis of pregnancy icp is a reversible type of hormonally influenced cholestasis it frequently develops in late pregnancy in individuals who are genetically predisposed virginia commonwealth university medical center fidelma b rigby md is a member of the following medical societies american college of . The medical management of cholestasis is largely supportive management is often related to the treatment of the complications of chronic cholestasis rather than the underlying mecha nism these complications include pruritus malabsorption and nutritional defi ciencies. Cholestasis learn about the causes symptoms diagnosis treatment from the merck manuals medical consumer version merck manual consumer version the trusted provider of medical information since 1899 people with cholestasis are advised to avoid or stop using any substance that is toxic to the liver such as alcohol and certain drugs. The first objective in the management of infants with cholestasis is the recognition of diseases amenable to specific medical therapy ie congenital toxoplasmosis urinary tract infection galactosemia tyrosinemia hypothyroidism or early surgical intervention biliary atresia choledochal cyst
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