The g protein coupled receptors gpcrs and associated peripheral g proteins underpin a multitude of physiological processes the gpcrs represent one of the largest superfamilies in the human genome and are a significant target for bioactive and drug discovery programs. Practical and fully updated g protein coupled receptors in drug discovery methods and protocols second edition serves as an ideal guide for a diverse audience from structural and molecular biologists to pharmacologists and drug designers who wish to explore this extensive class of key drug targets. G protein coupled receptors signaling trafficking and regulation a new volume in the methods in cell biology series continues the legacy of this premier serial with quality chapters authored by leaders in the field this volume covers research methods in g protein coupled receptors and includes sections on such topics signaling . The past two years have seen remarkable advances in the structural biology of g protein coupled receptors gpcrs highlights have included solving the first crystal structures of ligand activated gpcrs the human 2 adrenergic receptor 2 ar the avian 1 ar and the human a 2a adenosine receptor as well as the structures of opsin and an active form of rhodopsin. Current opinion in structural biology 2016 m maggiolinig protein coupled receptors novel targets for drug discovery in cancer nat rev drug discov 10 2011 pp 47 60 a grossfieldrecent progress in the study of g protein coupled receptors with molecular dynamics computer simulations biochim biophys acta biomembranes 1808 2011
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