The immunogenetics of primary biliary cirrhosis a comprehensive review current disease models envisage an immune driven biliary injury resulting in secondary cholestasis and which arises on the background of combined genetic and environmental risks cordell hj international genome wide meta analysis in primary biliary . 1994 english doctoral thesis comprehensive summary other academic place publisher year edition pages uppsala acta universitatis upsaliensis 1994 67 p series comprehensive summaries of uppsala dissertations from the faculty of medicine issn 0282 7476 496. Aspects of the pathophysiology of primary biliary cirrhosis corrigan m hirschfield gm primary biliary cirrhosis is a classical autoimmune liver disease and is present in around 1 in 1000 women over the age of 40. Thomas jefferson university jefferson digital commons department of medical genetics faculty papers department of medical genetics 8 1 2014 breach of tolerance primary biliary cirrhosis. Primary biliary cirrhosis primary biliary cirrhosis pbc is a chronic cholestatic liver disease of unknown etiology characterized by lymphocytic cholangitis and segmental destruction of intralobular bile ducts within the liver lm aleksunes in comprehensive toxicology 2010 908335 primary biliary cirrhosis because biliary
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