Center for regenerative medicine researchers are now designing and developing scalable manufacturing processes for bringing stem cell derived vesicles to the clinical setting as a novel therapeutic approach to treat liver injury living donor transplants liver cancer and advanced cases of cirrhotic liver disease may require liver transplants. Many stem cell treatments could potentially avoid the issue of immune rejection however a great amount of work must still be carried out to make sure that stem cell treatments particularly pluripotent stem cell treatments create reliable and predictable liver cells that are safe for transplantation in large enough quantities. Prof stuart forbes group at the mrc centre for regenerative medicine university of edinburgh liver stem cells and regeneration fortunately we have a second tier of cells that can regenerate the liver the hepatic progenitor cells hpcs or oval cells . Regenerative medicine liver researchers can generate functional liver cells from pluripotent stem cells including ipscs the human stem cell derived hepatic cells have been shown to extend the survival of mice with liver damage and do not produce any adverse events including teratoma formation. A new model of liver regeneration 2014 when the hippo pathway is inactivated mature liver cells revert back to a stem cell like state picture shows a group of cells transitioning from a mature cell type green to a stem cell type red that underlie that plasticity could be another way of potentially manipulating regeneration or
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