Core tip renal percutaneous denervation allows modulating the central sympathetic tone and is a promising new approach to our old strategy of inhibiting sympathetic system in this review we describe the pathophysiological knowledge that encouraged the development of this procedure we critically examine the available clinical evidence of the impact of renal denervation on resistant hypertension. Renal denervation rdn is a minimally invasive endovascular catheter based procedure using radiofrequency ablation aimed at treating resistant hypertension early studies show a high degree of effectiveness in renal denervation to treat hypertension. Renal denervation is a new treatment for resistant hypertension that targets the nerves near the kidneys responsible for regulating blood pressure surgeons once attempted to relieve hypertension by severing these renal artery nerves which resulted in lowering blood pressure too far. The use of renal denervation is an extremely promising approach to the treatment of patients with uncontrolled resistant hypertension said investigator john flack md associate chairman . Renal sympathetic denervation in patients with treatment resistant hypertension the symplicity htn 2 trial a randomized controlled trial two of these trials were proof of concept trials that evaluated a new approach to catheter based renal denervation jacobs l et al sham or no sham control that is the question in trials of renal
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