The challenge of drug induced liver injury dili challenges and management of liver cirrhosis preface gerbes al jaeschke h pmid 26159258 pubmed indexed for medline publication types introductory journal article mesh terms. When a patient with suspected drug induced liver injury dili undergoes liver biopsy the pathologist is confronted with two major challenges the first and most important is to establish the patterns of injury which are present. Aaslds pediatric liver disorders sig challenge of fontan associated liver disease presented at the liver meetingr 2018 may develop drug induced liver injury during clinical care or in clinical trials and it is associated with poor outcomes this program reviews the most recent advances in the clinical management of patients with . Drug induced liver injury dili is the most common cause of early termination of clinical drug trials and it accounts for more than 33 of cases of acute liver failure in clinical practice. Concurrence of pre existing chronic liver disease cld with drug induced liver injury dili is a special challenge in clinical settings which might render the liver sensitive to drug toxicity and cause higher fatality rates1 for instance a case report showed that long term alcohol intake could potentiate the hepatotoxicity of low doses of
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